Indicatios:
Glucose and Sodium Chloride Injection 5%+0.9% solution is indicated for:
Treatment of sodium depletion, extracellular dehydration or hypovolaemia in cases where supply of water and carbohydrates is required due to restriction of the intake of fluids and electrolytes by normal routes.
Dosage and administration:
The choice of the specific sodium chloride and glucose concentration, dosage, volume, rate and duration of administration depends on the age, weight, clinical condition of the patient and concomitant therapy. It should be determined by a physician. For patients with electrolyte and glucose abnormalities and for paediatric patients, consult a physician experienced in intravenous fluid therapy.
Fluid balance, serum glucose, serum sodium and other electrolytes should be monitored before and during administration, especially in patients with increased non-osmotic vasopressin release (syndrome of inappropriate antidiuretic hormone secretion, SIADH) and in patients co-medicated with vasopressin agonist drugs due to the risk of hyponatraemia. Monitoring of serum sodium is particularly important for physiologically hypotonic fluids. Glucose and Sodium Chloride Injection 5%+0.9% solution may become extremely hypotonic after administration due to glucose metabolisation in the body.
Rapid correction of hyponatraemia and hypernatraemia is potentially dangerous (risk of serious neurologic complications). Electrolyte supplementation may be indicated according to the clinical needs of the patient.
Method of administration
The administration is performed by intravenous infusion.
Drug interactions:
l Both the glycaemic and effects on water and electrolyte balance should be taken into account when administering Sodium chloride 0.9% w/v and Glucose 5% w/v solution to patients treated with other substances that affect glycaemic control, or fluid and/or electrolyte balance.
l Drugs leading to an increased vasopressin effect
Storage:
Store below 25°C in a dry place.